Retracted Article: Synthesis of diacylglycerol analogs bearing photoaffinity tags for labelling mammalian diacylglycerol kinase
| Autor: | Meng M. Rowland, Michael D. Best, Sammy Eni Eni |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Liposome Dependent manner General Chemical Engineering General Chemistry Plasma protein binding Phosphatidic acid chemistry.chemical_compound Enzyme Biochemistry chemistry Labelling lipids (amino acids peptides and proteins) Phosphatidylinositol Diacylglycerol kinase |
| Zdroj: | RSC Advances. 5:25457-25461 |
| ISSN: | 2046-2069 |
| Popis: | Signaling lipids such as diacylglycerol (DAG), phosphatidic acid, and the phosphatidylinositol polyphosphates are site-specific ligands for protein binding partners. Herein, we report the apotheoses of our initial approach to the development of diverse probes which are vital for understanding lipid–protein interactions. When incorporated into liposomes, these probes reduce mammalian diacylglycerol kinase's (DGK) enzymatic activity in a concentration, time, and light dependent manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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