Synthesis of novel pyridine-connected piperidine and 2H-thiopyran derivatives and their larvicidal, nematicidal, and antimicrobial activities
| Autor: | Aseer Manilal, Anis Ahamed, Idhayadhulla Akbar, Ibrahim A. Arif, Keerthana Selva raj, Radhakrishnan Surendra Kumar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Klebsiella Thiopyran Microsporum audouinii biology Chemistry General Chemistry medicine.disease_cause biology.organism_classification Antimicrobial 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Piperidine Antibacterial activity Candida albicans Escherichia coli Nuclear chemistry |
| Zdroj: | Journal of the Mexican Chemical Society. 62 |
| ISSN: | 2594-0317 1870-249X |
| DOI: | 10.29356/jmcs.v62i4.472 |
| Popis: | A series of novelpyridine-connected piperidine derivatives (2a-g) and pyridine-connected 2H-thiopyran derivatives (4a-g) were synthesized and screened for larvicidal, nematicidal, and antimicrobial activities. Compound 4e exhibited larvicidal activity against second instar larvae with an LD50 value of 0.8μg/mL. In addition, 4e exhibited high nematicidal activity, with an LD50 value of 3.2μg/mL.Compounds 2e (MIC: 4 μg/mL) and 2d (MIC: 4 μg/mL) exhibited high antibacterial activity against Klebsiella pneumoniae and Escherichia coli, respectively. Compounds 4b (MIC: 0.25 μg/mL) and 4f (MIC: 2 μg/mL) showed high antifungal activity against Candida albicans and Microsporum audouinii, respectively. Therefore, it can be suggested that compounds 2e, 2d, 4e, 4b, and 4f may be useful as lead molecules for the development of new classes ofdrugs with larvicidal,nematicidal,and antimicrobial activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|