Crystalcryoglobulinemia as a manifestation of monoclonal gammopathy of renal significance in a patient with renal cell carcinoma
| Autor: | Norma O. Uribe-Uribe, Silvia E. Ramirez-Andrade, Roque A Comunidad-Bonilla, Megan A Navarro-Gerrard, Abraham Cohen-Bucay, Juan M. Mejia-Vilet |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.disease Thrombosis Cryoglobulins 03 medical and health sciences Monoclonal gammopathy 0302 clinical medicine Renal cell carcinoma 030220 oncology & carcinogenesis Occlusion medicine Extracellular medicine.symptom business Deposition (chemistry) 030217 neurology & neurosurgery |
| Zdroj: | Journal of Onco-Nephrology. 5:140-144 |
| ISSN: | 2399-3707 2399-3693 |
| Popis: | Crystalcryoglobulinemia refers to the extracellular deposition of crystals in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. This entity is usually described as a complication of multiple myeloma, although it can also occur in the setting of a monoclonal gammopathy of renal significance. Synchronous presentation of a monoclonal gammopathy and renal cell carcinoma is rare. Hypothetically, as both neoplasms’ growth depends on certain cytokines such as interleukin-6, it is possible that cytokine production from one neoplasm may stimulate the growth of the other. In this report, we describe a case of crystalcryoglobulinemia in a patient with a monoclonal gammopathy of renal significance and concomitant renal cell carcinoma. Additionally, we performed a systematic review of the literature and analyzed data of 61 reported cases of crystalcryoglobulinemia and of 40 reported cases describing the association between multiple myeloma and renal cell carcinoma. |
| Databáze: | OpenAIRE |
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