Autor:	N. V. Nikol'skaya, V. M. Denisov, M. V. Solovskii
Rok vydání:	2000
Předmět:	Pharmacology medicine.drug_class Antibiotics Aminoglycoside Pharmacology toxicology N-Vinylpyrrolidone chemistry.chemical_compound chemistry Drug Discovery Toxicity medicine Copolymer Organic chemistry Gentamicin Biologically active substances medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 34:592-595
ISSN:	0091-150X
DOI:	10.1023/a:1010392105145
Popis:	One way of decreasing the toxicity of biologically active substances (BAS), including antibiotics and antiseptics, is to form complexes (salts) with low-toxicity water-soluble reactive copolymers of N-vinylpyrrolidone (VP) [1 – 4]. Reduction in toxicity is particularly relevant to aminoglycoside antibiotics, especially gentamicin, a substance consisting of a mixture of homologs – C1, C1A, and C2, of general formula I.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f7003c9d5a5e6ca0e6d516690c7efbca https://doi.org/10.1023/a:1010392105145 Zobrazit plný text záznamu Full text from SpringerLink