Interactions between protein kinase C and the T3/T cell antigen receptor complex
| Autor: | A. A. Davies, M. J. Crumpton, Doreen A. Cantrell, G. Krissansen |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
inorganic chemicals
biology MAP kinase kinase kinase Chemistry Cyclin-dependent kinase 5 Cyclin-dependent kinase 2 Mitogen-activated protein kinase kinase Molecular biology enzymes and coenzymes (carbohydrates) biology.protein Cyclin-dependent kinase complex Cyclin-dependent kinase 9 c-Raf Protein kinase C |
| Zdroj: | Regulation of Immune Gene Expression ISBN: 9781461293996 |
| DOI: | 10.1007/978-1-4612-5014-2_11 |
| Popis: | Activators of protein kinase C induce T cells to become refractory to mitogenic anti-T3 antibodies. A possible mechanism for this unresponsiveness is suggested by the observations that activation of C kinase results in a rapid down regulation of the surface expression of the T3/T cell antigen receptor complex. As well, there is a concommitant phosphorylation of the T3γ and d polypeptides; the γ chain was more extensively phosphorylated than the d chain. No phosphorylation of the T3e chain and the Ti, α and β polypeptides was detected. Evidence was obtained that the T3γ chain is phosphorylated only on serine residues. |
| Databáze: | OpenAIRE |
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