Changes in Neurohypophysial Proteins Induced by Dehydration and Ingestion of Saline1

Autor:	Henry Friesen, E. B. Astwood
Rok vydání:	1967
Předmět:	chemistry.chemical_classification medicine.medical_specialty Pituitary gland Vasopressin medicine.medical_treatment Peptide Biology medicine.disease Endocrinology medicine.anatomical_structure chemistry Posterior pituitary Internal medicine Diabetes insipidus medicine Ingestion Dehydration Saline
Zdroj:	Endocrinology. 80:278-287
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-80-2-278
Popis:	Sustained dehydration or prolonged ingestion of salt solution in rats resulted in marked changes in the appearance of the posterior lobe of the pituitary and an increase in its size and weight. Also, several protein components of the posterior pituitary decreased in concentration; with rehydration or replacement of saline with water they returned to normal. Similar changes were observed in pituitaries from several other species, including the pig, dog and rabbit. Peptide II, previously identified as a lipolytic factor in porcine pituitaries and which is the principal soluble protein component of the posterior pituitary, decreased most markedly with dehydration. It is suggested that in eachspecies the homologous polypeptides which vary with the state of hydration constitute the “neurosecretory material.” In rats with congenital diabetes insipidus (Brattleboro strain) the concentration of these peptides was greatly reduced and prolonged administration of exogenous vasopressin did not restore them to normal....
Databáze:	OpenAIRE
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