Digestibility and Suppressive Effect on Rats' Body Fat Accumulation of Cyclic Tetrasaccharide

Autor:	Tomoyuki Nishimoto, Takaharu Hashimoto, Hiroto Chaen, Mayumi Kurose, Yoshio Tsujisaka, Shigeharu Fukuda, Kazuyuki Oku
Rok vydání:	2006
Předmět:	Single administration chemistry.chemical_classification medicine.medical_specialty Triglyceride nervous system diseases chemistry.chemical_compound Hydrolysis Enzyme Endocrinology Fat accumulation chemistry Internal medicine medicine Tetrasaccharide Fermentation Feces
Zdroj:	Journal of Applied Glycoscience. 53:233-239
ISSN:	1880-7291 1344-7882
Popis:	We examined the digestibility of cyclic tetrasaccharide (CTS; cyclo{→6)-α-D-Glcp-(1→3)-α-D-Glcp-(1→6)-α-D-Glcp-(1→3)-α-D-Glcp-(1→}). CTS was resistant to two types of α-amylase and to artificial gastric juice. Enzymes in the rat small intestinal mucosa slightly hydrolyzed CTS. CTS was not utilized by 22 strains of human intestinal bacteria. CTS was not fermented by rat cecal content. In the single administration to rats, more than 90% of the administered CTS was recovered in the feces. From the above results, CTS was confirmed as an indigestible and unfermentable saccharide. As a result of 4 weeks’ feeding to rats, CTS was effective in the suppression of body fat accumulation and lowering of serum triglyceride of the rats. These effects of CTS depended on the amount of CTS in the diet.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6f38d8bdc771a5acea6218b639ebec6 https://doi.org/10.5458/jag.53.233 Zobrazit plný text záznamu