Plasma Lipoproteins in Familial Lecithin:Cholesterol Acyltransferase Deficiency: Effects of Incubation with Lecithin: Cholesterol Acyltransferase in vitro
| Autor: | Kaare R. Norum, Alex V. Nichols, Elaine L. Gong, Weiling C. King, V G Cabana, Kenneth R. Applegate, John A. Glomset, Carolyn D. Mitchell, Egil Gjone, Trudy M. Forte, John J. Albers |
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| Rok vydání: | 1975 |
| Předmět: |
Intermediate-density lipoprotein
Very low-density lipoprotein medicine.medical_specialty Lecithin cholesterol acyltransferase deficiency Apolipoprotein B biology Chemistry Clinical Biochemistry Reverse cholesterol transport Sterol O-acyltransferase General Medicine medicine.disease chemistry.chemical_compound Endocrinology Internal medicine biology.protein medicine Cholesteryl ester lipids (amino acids peptides and proteins) Lipoprotein |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 35:31-55 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365517509108158 |
| Popis: | To study the effect of lecithin: cholesterol acyltransferase (LCAT) on the plasma lipoproteins of patients with familial LCAT deficiency, whole plasma or the lipoprotein fraction of d < 1.006 g/ml (VLDL) was incubated in the presence of LCAT and subsequently examined by chemical, physical, and immunological techniques. The following occurred upon incubating either hyperlipemia or nonlipemic plasma: The concentrations of polar lipids decreased, particularly in the large molecular weight lipoprotein subfraction of d 1.019-1.063 g/ml (LDL2) and in the lipoprotein fraction of d 1.063-1.25 g/ml (HDL). The concentration of cholesteryl ester (CE) increased, particularly in the VLDL and in the lipoprotein fractions of d 1.006-1.019 g/ml (LDL1) and LDL2. The concentration of arginine-rich apolipoprotein decreased in the HDL and increased in the VLDL and LDLi. The concentrations of the C-apoliproteins appeared to change in the opposite direction. The concentration of apolipoprotein B in the LDL increased concomitan... |
| Databáze: | OpenAIRE |
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