Synergic antiherpetic effect of para-aminobenzoic acid and modified nucleosides

Autor:	Stroeva Og, Leont'eva Na, Akberova Si, Galegov Ga
Rok vydání:	1997
Předmět:	viruses General Medicine Biology medicine.disease_cause Virology Modified nucleosides General Biochemistry Genetics and Molecular Biology Virus Microbiology Herpes simplex virus medicine Vero cell Combined therapy PARA-AMINOBENZOIC ACID
Zdroj:	Bulletin of Experimental Biology and Medicine. 124:789-791
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445093
Popis:	New results of combined therapy of herpetic infection in Vero cells infected with herpes simplex type I virus resistant to acyclovir (acycloguanosine, Zovirax) are presented. Paraaminobenzoic acid stimulates antiherpetic effects of acycloguanosine, 5-(2-bromovinyl)-2′-deoxyuridine and adenine 9-β-d-arabinofuranoside. para-aminobenzoic acid alone is incapable of suppressing type I herpes simplex virus reproduction in cell culture. Modified nucleosides combined with it exert a higher selective antiherpetic effect. Para-aminobenzoic acid is capable of inactivating herpes viruses in culture medium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6eb9f65b42a9c53a091179e610eb66f https://doi.org/10.1007/bf02445093 Zobrazit plný text záznamu Full text from SpringerLink