The Role of Circulating Adiponectin and SNP276G>T at ADIPOQ Gene in BRCA-mutant Women
| Autor: | Porzia Casamassima, Brunella Pilato, Maria Digennaro, Antonella Daniele, Rosa Divella, Eufemia Savino, Eleonora Bruno, Margherita Patruno, Carla Minoia, Patrizia Pasanisi, Stefania Tommasi, Michele Barone, Antonio Tufaro, Andreina Oliverio, Donatella Colangelo, Angelo Paradiso |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Adiponectin business.industry Leptin BRCA mutation Case-control study Adipokine Odds ratio Biochemistry Penetrance 03 medical and health sciences 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Internal medicine Genotype Genetics Medicine business Molecular Biology |
| Zdroj: | Cancer Genomics - Proteomics. 17:301-307 |
| ISSN: | 1790-6245 1109-6535 |
| Popis: | Background Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. Materials and methods In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G>T as modulators of BRCA penetrance. Results Affected women had significantly lower adiponectin than healthy women. Affected women with rs1501299 TT had significantly lower adiponectin and higher leptin than GT and GG genotypes. GT genotype was significantly associated with the disease status [odds ratio (OR)=3.24, 95% confidence interval (95% CI)=1.03-10.17]. Women in the lower tertile of serum adiponectin had a RR of BRCA-associated cancer of 2.80, 95% CI=1.1-7.1 (p for trend=0.03) compared with women in the higher tertile. Conclusion In the SNP rs1501299 the T allele was significantly associated with lower serum levels of adiponectin in affected women, suggesting that the T allele might be related to cancer. |
| Databáze: | OpenAIRE |
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