Analytics of biologically active derivatives of electrostatically stabilized silanates by isotachophoresis
| Autor: | Nikolai Erchak, Joanna Jabłońska, Mariusz Kluska |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Detection limit
Aqueous solution Chromatography 010405 organic chemistry Capillary action Chemistry 010401 analytical chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Electrolyte 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Physical chemistry Isotachophoresis |
| Zdroj: | Journal of Liquid Chromatography & Related Technologies. 41:1098-1103 |
| ISSN: | 1520-572X 1082-6076 |
| DOI: | 10.1080/10826076.2019.1566139 |
| Popis: | The paper presents optimum conditions for separation and determination of three dimethyl derivatives of ES-silanates by capillary isotachophoresis. The following were considered in the study: 1-[(N,N-dimethyl)aminiomethyl]-spirobi(1-sila-2,5-dioxacyclopentan-3-on)at, 1-[(N,N-dimethyl)aminiomethyl]-spirobi(1-sila-2,5-dioxa-4-methylcyclopentan-3-on)at, and 1-[(N,N-dimethyl)aminiomethyl]-spirobi(1-sila-2,5-dioxa-4,4-dimethylcyclopentan-3-on)at. An aqueous solution of 4,4'-bis{1-[(N,N-dimethyl)aminiomethyl]spirobi(1-sila-2,5-dioxacyclopentan-3-on)at} was proposed as a terminating electrolyte in the determination process. The optimum time of analysis did not exceed 7 min. The limit of identification of ES-silanates was 2.0 µg · L−1 and the limit of quantification was 6.6 µg · L−1. The newly developed method allows for a more extensive research on the biological activity of hypercoordinated compounds belonging to ES-silanates and increases their applicability (e.g., as terminating electrolytes). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|