Synthesis of enantiomerically pure desmethyl C,D-ring derivative of paclitaxel (taxolTM) via asymmetric Diels-Alder reaction of 2-siloxyfuran

Autor:	Chin-Kang Sha, Shin-Jen Lee, Wei-Hong Tseng
Rok vydání:	1997
Předmět:	Dimethyl acetylenedicarboxylate chemistry.chemical_compound chemistry Paclitaxel Organic Chemistry Drug Discovery Organic chemistry Desmethyl Biochemistry Derivative (chemistry) Diels–Alder reaction
Zdroj:	Tetrahedron Letters. 38:2725-2728
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)00454-1
Popis:	Cycloadduct 3 of the asymmetric Diels-Alder reaction of 2-siloxyfuran 2 and dimethyl acetylenedicarboxylate was converted into the enantiomerically pure desmethyl C,D-ring derivative 13 of Paclitaxel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6ca5d4f3dd88997736da893823a34f8 https://doi.org/10.1016/s0040-4039(97)00454-1 Zobrazit plný text záznamu Full Text from ScienceDirect