Optimizing Preparative LC/MS Configurations and Methods for Parallel Synthesis Purification

Autor:	Andrew P. Combs, and Tasir Haque, James Doughty, J. Gerard Everlof, Karl F. Blom, Sparks Richard B
Rok vydání:	2003
Předmět:	Chromatography Liquid chromatography–mass spectrometry Chemistry Analytical chemistry Ms analysis Fraction (chemistry) General Chemistry Fractionation Mass loading
Zdroj:	Journal of Combinatorial Chemistry. 5:670-683
ISSN:	1520-4774 1520-4766
DOI:	10.1021/cc020086n
Popis:	Preparative LC/MS is widely employed to address the high-throughput purification demands of parallel synthesis. However, conflicting chromatography requirements and the complexities of applying MS-directed fractionation can limit its effectiveness in high-throughput parallel synthesis schemes. We report here an at-column dilution small-scale preparative LC configuration which satisfies the mass loading (>20 mg) and small fraction volume (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6bfa8e16e927051a974319fe4e7900a https://doi.org/10.1021/cc020086n Zobrazit plný text záznamu