Broad Cross-Reactive TCR Repertoires Recognizing Dissimilar Epstein-Barr and Influenza A Virus Epitopes
| Autor: | David A. Thorley-Lawson, Shalyn Catherine Clute, Franco Celada, Nuray Aslan, John L. Sullivan, Levi B. Watkin, Katherine Luzuriaga, Roberto Puzone, Raymond M. Welsh, Yuri N. Naumov, Liisa K. Selin |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 185:6753-6764 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show in this article, by examining human T cell cross-reactivity between the HLA-A2–restricted influenza A virus-encoded M158–66 epitope (GILGFVFTL) and the dissimilar Epstein-Barr virus-encoded BMLF1280–288 epitope (GLCTLVAML), that, under some conditions, heterologous immunity can lead to a significant broadening, rather than a narrowing, of the TCR repertoire. We suggest that dissimilar cross-reactive epitopes might generate a broad, rather than a narrow, T cell repertoire if there is a lack of dominant high-affinity clones; this hypothesis is supported by computer simulation. |
| Databáze: | OpenAIRE |
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