Effects of pilose antler extracts on doxorubicin-induced beating abnormalities of cultured myocardial cells

Autor: Xiu-Wei Yang, Nobuko Kakiuchi, Sheng-Lun Huang, Masao Hattori, Tsuneo Namba, Kyoko Takahashi
Rok vydání: 1990
Předmět:
Zdroj: Phytotherapy Research. 4:152-156
ISSN: 1099-1573
0951-418X
DOI: 10.1002/ptr.2650040406
Popis: Effects of pilose antler extracts and subsequent fractions on normal and doxorubicin (DX)-administered cultured myocardial cells from mouse embryo were investigated. A water extract did not affect the percentage of beating cells at 1–100 μg/mL but suppressed the beating rate at 100 μ/mL. A pretreatment with the water extract significantly restored the percentage of beating cells which was reduced by administration of DX, and showed a tendency to recover the reduced beating rate. A similar pretreatment with an aqueous EtOH-solnble portion (fraction 1) of the water extract significantly recovered both the percentage of beating cells and the beating rate, but further fractionation did not improve the activities. LDH leakage from DX-administered myocardial cells was significantly diminished by the pretreatment with fraction 1, though ATP content in the cells was not appreciably recovered.
Databáze: OpenAIRE
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