ChemInform Abstract: Synthesis and Screening of 3-Substituted Thioxanthen-9-one-10,10-dioxides

Autor:	Estrella-Jimenez Maria, Matthew J. Shashack, Pedro M. J. Lory, G. L. Lokesh, Scott R. Gilbertson, Amarnath Natarajan
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Hepatitis C virus General Medicine medicine.disease medicine.disease_cause Breast cancer chemistry Biochemistry SECRETED ALKALINE PHOSPHATASE medicine Replicon Gene Fluorescence anisotropy Tricyclic
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
Popis:	This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6bc0d7d6b7508a2d61b12c4e783a055 https://doi.org/10.1002/chin.200806125 Zobrazit plný text záznamu Plný text