Synthesis of Heteroaryl-fused Pyrazoles as P38 Kinase Inhibitors

Autor:	Nolan James Dewdney, Teresa Alejandra Trejo-Martin, Roland J. Billedeau, Michael Soth, Hasim Zecic, Sarah C. Abbot, Tobias Gabriel, David Michael Goldstein, Kristen Lynn Mccaleb
Rok vydání:	2009
Předmět:	Pharmacology Pyrimidine Pyrazine Stereochemistry Organic Chemistry Leaving group Pyrazole Pyrazolopyrimidine Analytical Chemistry Adduct Pyridazine chemistry.chemical_compound chemistry Pyrazolopyridine
Zdroj:	HETEROCYCLES. 78:2811
ISSN:	0385-5414
DOI:	10.3987/com-09-11808
Popis:	The synthesis of pyrazolo-pyridine, pyrimidine, pyrazine and pyridazine heterocycles is described. In addition, we report the utilization of 2,4-difluorophenoxide as a leaving group, to facilitate formation of the desired pyrazole adducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6b51e4d50970007f3559152dc4a0cba https://doi.org/10.3987/com-09-11808 Zobrazit plný text záznamu