| Autor: |
G. B. Vegt, A. M. Wassenaar, E. W. M. Kawilarang-de Haas, P. P. Schütte, M. van der Linden, M. Di Bon-de Ruijter, A. Boon, P. P. Schutte |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
Radiation Research. 104:317 |
| ISSN: |
0033-7587 |
| DOI: |
10.2307/3576593 |
| Popis: |
We investigated the effect of irradiation on the kinetic characteristics of amino acid and glucose transport, and the effect on the activity of the cell membrane-bound enzyme 5'-nucleotidase and on the receptor-mediated stimulation of cyclic adenosine monophosphate synthesis by prostaglandin E1. Irradiation inhibited the sodium-dependent amino acid transport by a reduced binding of the amino acid to the transport unit. The transport of glucose, which appeared to be a sodium-independent process, was temporarily stimulated by increased maximal velocity of the transport. No effect was found on the binding to the transport unit. Irradiation increased the 5'-nucleotidase activity and decreased the prostaglandin E1-stimulated cyclic adenosine monophosphate synthesis 48 h after exposure to 20 Gy. It is concluded that irradiation decreases sodium-dependent transport by impairment of the transport unit, does not impair a sodium-independent process, and has opposite effects on membrane-bound enzyme activity and a receptor-mediated process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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