The biochemical mechanisms of the toxic effects of some pyridine derivatives. 1. Study on the deamination of biogenic amines and other nitrogenous compounds in paraquat intoxication

Autor:	Gorkin Vz, A. Medvedev, M. Mamadiev, M. Khuzhamberdiev, K. Amanov
Rok vydání:	1994
Předmět:	chemistry.chemical_classification Sodium ascorbate Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Deamination General Medicine Tyramine Toxicology Pollution Lipid peroxidation chemistry.chemical_compound Biochemistry Paraquat chemistry Biogenic amine Toxicity medicine
Zdroj:	Archives of Environmental Contamination and Toxicology. 26:534-539
ISSN:	1432-0703 0090-4341
DOI:	10.1007/bf00214158
Popis:	Lethal intoxication of rats with the herbicide paraquat (1,1′-dimethyl-4,4′-bipyridilium dichloride) caused a stimulation of lipid peroxidation (LPO) in lung, brain, heart, liver, and kidney. Treatment of animals with antioxidant diludin (2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine) or with the reductants sodium ascorbate or thiosulphate normalized the rate of LPO in these tissues and decreased mortality of intoxicated rats.
Databáze:	OpenAIRE
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