REGULATION OF LYMPHOCYTE RESPONSES IN VITRO

Autor:	Masaru Yoshinaga, Byron H. Waksman, Aiko Yoshinaga
Rok vydání:	1972
Předmět:	medicine.medical_specialty DNA synthesis Lymphocyte Immunology Lymphokine Spleen Biology In vitro Cell biology medicine.anatomical_structure Endocrinology Internal medicine medicine Myeloid-derived Suppressor Cell Immunology and Allergy Bone marrow Cell adhesion
Zdroj:	Journal of Experimental Medicine. 136:956-961
ISSN:	1540-9538 0022-1007
DOI:	10.1084/jem.136.4.956
Popis:	DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T-deprived spleen. We conclude that two mechanisms of suppression are at work: a direct effect of macrophages and a macrophage-dependent "suppressor T cell" effect.
Databáze:	OpenAIRE
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