Interferon-αcon-1 Treatment of Three Patients with Severe Glucocorticoid-Dependent Asthma

Autor:	Angelika Reissig, Claus Kroegel, Andreas Machnik, Bettina Mock, Nicole Bergmann, Grefachew Workalemahu, Martin Foerster
Rok vydání:	2006
Předmět:	Pulmonary and Respiratory Medicine Systemic disease business.industry Respiratory disease Therapeutic effect Severe persistent asthma medicine.disease Lung disease Interferon Immunology medicine business Glucocorticoid medicine.drug Asthma
Zdroj:	Respiration. 73:566-570
ISSN:	1423-0356 0025-7931
Popis:	We report herein the therapeutic effect of interferon (IFN)-αcon in three patients with severe persistent asthma and long-term oral glucocorticoid treatment. IFN-αcon (9 µg) administered subcutaneously thrice a week over a period of more than 24 months led to a substantial clinical improvement with regard to the number of daily asthma attacks, nighttime disturbance, emergency visits and hospitalizations. In addition, lung function and exercise capacity improved. At the same time, treatment with IFN allowed discontinuation of the daily glucocorticoid dose in all patients for the first time in more than 8 years. Our findings suggest that IFN-αcon leads to a significant clinical improvement while at the same time allowing reduction and discontinuation of the glucocorticoid treatment in severe persistent glucocorticoid-dependent asthma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f695cc5813c15041f399c2bff4661e76 https://doi.org/10.1159/000088660 Zobrazit plný text záznamu