| Autor: |
Jenny Tam, Manuel Ramses Martinez, Subodh J. Saggi, Laura H. Goetz, David Perry, Isabel Chico-Calero, Rachelle Mendoza, Elmer Gabutan, Noriyuki Murakami, Eve S. Faber, Richard M. Novak, Heather Centner, Timothy K. McDaniel, Jenny Libien, Donald E. Ingber, David M. Engelthaler, William Fyke |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.07.19.21260235 |
| Popis: |
The SARS-CoV-2 pandemic revealed the fragility of global supply chains, resulting in shortages of essential clinical supplies for the detection and treatment of COVID-19, including nasopharyngeal swabs (NP) commonly used to collect clinical samples for respiratory disease diagnostics. Groups around the world led a response to find alternatives to these shortages. Here, we describe the development of a single-component nasopharyngeal swab (GrooveSwab) composed of medical grade polypropylene that can be mass manufactured using conventional injection molding. The design inspired by cat tongue papillae consists of a non-absorbent stacked ring structure that allows for efficient and comfortable collection of viscous mucus samples and faster release into collection medium compared to traditional absorbent swabs. GroveSwabs were evaluated in 2 clinical studies in the US and Peru and demonstrated 90% or better concordance with commercial swabs. The simplified NP swab offers a reliable, lower cost, and more manufacturable alternative to absorbent swabs to avoid future shortages. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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