Second primary malignancies after high-dose-rate 60Co photon or 252Cf neutron brachytherapy in conjunction with external-beam radiotherapy for endometrial cancer
| Autor: | Vydmantas Atkočius, Ernestas Janulionis, Konstantinas Povilas Valuckas, Mark J. Rivard, Vitalija Samerdokiene |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Endometrial cancer medicine.medical_treatment Incidence (epidemiology) Urinary system Brachytherapy medicine.disease 030218 nuclear medicine & medical imaging Vulva Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cohort medicine Radiology Nuclear Medicine and imaging External beam radiotherapy Radiology business |
| Zdroj: | Brachytherapy. 17:768-774 |
| ISSN: | 1538-4721 |
| DOI: | 10.1016/j.brachy.2018.05.004 |
| Popis: | Purpose Second primary malignancies (SPMs) may occur in organs after radiotherapy (RT). This study aimed to determine the rate and distribution of SPMs for photon- or neutron-emitting radiotherapy sources for patients treated for primary endometrial cancer. Methods and Materials The cohort comprised 426 patients with 5334 patient-years of observation. Patients were treated by different methods of RT from 1990 to 2000. Patients received postoperative 60Co external-beam radiotherapy (43.4%), external-beam radiotherapy + high-dose-rate (HDR) intracavitary brachytherapy with 60Co or 252Cf (42.3%), or HDR intracavitary brachytherapy alone with 60Co or 252Cf (14.3%). Results Over a 25-year period, 47 SPMs were observed (21 for HDR 60Co and 26 for HDR 252Cf). SPMs were observed for 13 patients in the high-intermediate risk group for each radiation source. Patients treated with 60Co developed SPMs in the urinary tract (1.2%) and in lymphoid/hematopoietic tissues (1.2%). Only three SPM cases (0.7%) were observed in digestive tract. In comparison, the patient group treated with 252Cf developed SPMs in the digestive tract (1.4%) with the majority in the colon (1.2%), urinary tract (0.9%) primarily the kidneys, and vulva (0.7%). All other SPMs (4.9%) were in the low-risk group. Of these, SPMs in the skin were most prevalent (1.6%) for 60Co, and breast (1.6%) for 252Cf, but believed to be caused by factors other than treatment. SPM incidence in the digestive and urinary tracts were similar (2.1%), regardless of radiation source. Conclusions For followup at 25 years, 47 SPMs were observed with no differences in the high-intermediate risk group depending on the RT source. |
| Databáze: | OpenAIRE |
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