Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Autor:	Yao Guo, Dengyang Zhang, Chun Chen, Xiaojun Xu, Han Zhong Pei, Zhiguang Chang, Zhizhuang Joe Zhao, Hongman Xue, Junbin Huang, Liqin Zhang, Yun Chen, Liuting Yu, Yuming Zhao
Rok vydání:	2020
Předmět:	biology business.industry Lymphoblastic Leukemia Immunology Cell Biology Hematology B-cell acute lymphoblastic leukemia Malignancy medicine.disease Biochemistry Receptor tyrosine kinase Tyrosine Kinase 3 biology.protein medicine Cancer research In patient Flt3 ligand business Pathological
Zdroj:	Blood. 136:36-37
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood-2020-142093
Popis:	B-cell acute lymphoblastic leukemia (B-ALL) is a malignancy of B lymphocytes blocked at an early stage of differentiation, which accounts for approximately 30% of childhood cancers. Almost all B-ALL blasts aberrantly express FMS-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase involved in the development of dendritic cells and B lymphocytes. In B-ALL, the high expression of FLT3 in blasts significantly increases the odds of relapse/death in patients, indicating a pathological role of FLT3 in B-ALL. Note that gain-of-function mutations of FLT3 are relatively rare ( Disclosures No relevant conflicts of interest to declare.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f687a3c2431476379be52987019b3cd7 https://doi.org/10.1182/blood-2020-142093 Zobrazit plný text záznamu