Properties of Langmuir and immobilized layers of betulin diphosphate on aqueous solutions of zinc sulfate and on the surface of zinc oxide nanoparticles
| Autor: | Dmitry V. Orekhov, A. V. Knyazev, N. B. Melnikova, D. S. Malygina, K. L. Belyaeva, A. G. Solovyeva, O. A. Vorobyova |
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| Rok vydání: | 2021 |
| Předmět: |
Langmuir
Betulin Aqueous solution 010405 organic chemistry Chemistry chemistry.chemical_element Nanoparticle General Chemistry Zinc respiratory system 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Ultraviolet visible spectroscopy Monolayer Wurtzite crystal structure Nuclear chemistry |
| Zdroj: | Russian Chemical Bulletin. 70:289-300 |
| ISSN: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-021-3084-8 |
| Popis: | This work examines the specific features of interaction of betulin diphosphate (BDP), exhibiting antitumor and wound-healing properties, with zinc cations during its immobilization on ZnO nanoparticles. The properties of Langmuir and transferred BDP monolayers from an aqueous subphase of zinc sulfate onto the surface of a solid substrate (CaF2, quartz) by the Langmuir—Schaefer method are investigated using IR and UV spectroscopy. It is shown that there is a twofold increase of the molecular area in the immobilized layers, while the compressibility modulus decreases by a factor of 1.5. Zinc oxide nanoparticles with immobilized BDP 10–20 nm in size (surface concentration of BDP is 100 mg g−1) retain the original hexagonal wurtzite structure. The efficiency of betulin diphosphate immobilized on the surface of zinc oxide nanoparticles is demonstrated in in vivo experiments for burn wounds in rats. |
| Databáze: | OpenAIRE |
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