| Autor: |
Penumula Ramanamma, Mariza Pires de Melo, Patrícia Goldschmidt Lins, Silvana Marina Piccoli Pugine, Yerra Sai Sumanjali, Tatikonda Nagendra Babu, Antonio Márcio Scatolini, Prasada Rao Manchineni, Somepalli Veeranjaneyulu, Satti Ravindra Kumar, Raghavendra Kumar Gunda |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Analytical & Pharmaceutical Research. 9:60-66 |
| ISSN: |
2473-0831 |
| Popis: |
Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Lamotrigine. Lamotrigine, an antiepileptic agent, belongs to type –II as per Biopharmaceutical Classification System (BCS). Methods: ODT formulations of Lamotrigine were prepared using different quantities of Sodium Starch Glycolate & Crospovidone employed as Super disintegrants by Direct Compression technique. Nine trials were formulated and evaluated for Pharmaceutical Product Performance. Results: Results shows that all the formulations were lie within the acceptance criterion and the In-vitro dissolution profiles were subjected to kinetic modeling. Conclusion: Formulation (F4) containing 35 mg of Sodium Starch Glycolate & 40 mg of Crospovidone was found to be best one among all and also similar to the Marketed product (LAMICTAL-25) (f2=73.17, f1=3.65 & No significant difference, t=0.0218) to marketed product. Formulation (F4) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.554). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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