3D Histomorphometric Reconstruction and Quantification of the Optic Nerve Head Connective Tissues
| Autor: | Claude F. Burgoyne, Luke Reyes, Juan Reynaud, Christy Hardin, Howard Lockwood, Hongli Yang, Stuart K. Gardiner, Galen Williams |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
genetic structures business.industry 3D reconstruction Glaucoma Connective tissue medicine.disease eye diseases Sclera Imaging modalities 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030221 ophthalmology & optometry medicine Optic nerve Head (vessel) sense organs 3d geometry business Biomedical engineering |
| Zdroj: | Glaucoma ISBN: 9781493974061 |
| DOI: | 10.1007/978-1-4939-7407-8_17 |
| Popis: | Accurately characterizing the 3D geometry of the optic nerve head neural and connective tissues has been the goal of a large and important body of scientific work. In the present report, we summarize our methods for the high-resolution, digital, 3D histomorphometric reconstruction of the optic nerve head tissues, including their visualization, parameterization, and quantification. In addition, we present our methods for between-eye comparisons of this anatomy, and their use to determine animal-specific and experiment-wide experimental glaucoma versus Control eye differences in the unilateral, monkey experimental glaucoma model. Finally, we demonstrate its application to finite element modeling, 3D optic nerve head reconstruction of other species, and 3D optic nerve head reconstructions using other imaging modalities. |
| Databáze: | OpenAIRE |
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