Large-scale preparation of13C-labeled 2-(phenylthio)acetic acid and the corresponding labeled sulfoxides and sulfones

Autor:	Siegfried N. Lodwig, Ernesto Juarez, David R. Glass, Marc A. Alvarez, Rodolfo A. Martinez, Erick Gabriel Ortiz, Clifford J. Unkefer
Rok vydání:	2013
Předmět:	Organic Chemistry Biochemistry Analytical Chemistry chemistry.chemical_compound Acetic acid chemistry Bromoacetic acid Methacrylic acid Drug Discovery Stable Isotope Labeling Organic chemistry Radiology Nuclear Medicine and imaging Methanol Spectroscopy Acrylic acid
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 56:31-35
ISSN:	0362-4803
Popis:	We have developed large-scale efficient procedures for the conversion of commercially available [(13) C]- or [(2) H3 ,(13) C]methanol and (13) CO2 or (13) C-labeled bromoacetic acid to 2-(phenylthio)[1,2-(13) C2 ]-, [1-(13) C]-, and [2-(13) C]acetic acid. The resulting derivatives are versatile, chemically stable, and nonvolatile two-carbon labeling precursors. We have used the (13) C-isotopomers of 2-(phenylthio)acetic acid in the synthesis of (13) C-labeled acrylic acid, methacrylic acid, and trans-crotonic acid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f6742f1c1f5269d91b6dc407a9b661f8 https://doi.org/10.1002/jlcr.2991 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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