Can trichomonas immunochromatographic test increase the validity and reliability of WHO syndromic algorithm for vaginal discharge as a screening tool for trichomoniasis?
| Autor: | Renu Wickremasinghe, Neluka Fernando, H Banneheke, Ankur Barua, Upul Gunasekara, R. C. Fernandopulle |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Sexually transmitted disease Vaginal discharge Trichomoniasis biology business.industry 030106 microbiology Trichomonas Public Health Environmental and Occupational Health Trichomonas Infection Validity General Medicine biology.organism_classification medicine.disease Stratified sampling 03 medical and health sciences 0302 clinical medicine parasitic diseases Medicine 030212 general & internal medicine False positive rate medicine.symptom business Algorithm |
| Zdroj: | Annals of Tropical Medicine and Public Health. 9:43 |
| ISSN: | 1755-6783 |
| DOI: | 10.4103/1755-6783.168717 |
| Popis: | Background: Trichomoniasis is a sexually transmitted parasitic infection. The World Health Organization (WHO) advocated flow charts for curable sexually transmitted infections (STIs) to improve the care. In this study, an attempt was made to evaluate the validity and reliability of WHO syndromic algorithm for vaginal discharge against trichomonas immunochromatographic test (ICT). Trichomonas ICT is a test with high validity, reliability, and feasibility. Objectives: The objective was to evaluate the validity and reliability of WHO syndromic algorithm for vaginal discharge against trichomonas ICT as a screening tool for trichomonas infection among women of reproductive age in the Western Province, Sri Lanka. Materials and Methods: This cross-sectional study was conducted in sexually transmitted disease clinics, well woman clinics, gynecology clinics, and institutional health clinics in the Western Province, Sri Lanka. We enrolled 100 women in the age group of 15-45 years using the stratified random sampling method. They were interviewed and examined and the specimens were collected to identify trichomoniasis by culture and ICT. Two-stage analyses were done to evaluate the performance of the WHO algorithm against Trichomonas ICT. Results: In a two-stage analysis, the specificity of syndromic algorithm improved from 80.9% to 94.4% while false positive rate reduced from 19.1% to 5.6%. The net effect of specificity was 98.7% while the false positive rate was 1.3%. Conclusion: The validity and reliability of WHO syndromic algorithm as a diagnostic tool for trichomoniasis can be improved by adding trichomonas ICT. |
| Databáze: | OpenAIRE |
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