A fast and high throughput LC-MS/MS method for the determination of 58 human and veterinary drugs in river water
| Autor: | Xiaohong Chen, Yong-Gang Zhao, Jian-Qing Min, Micong Jin, Yan Zhu, Qiao-Li Qiu |
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| Rok vydání: | 2017 |
| Předmět: |
Analyte
Chromatography Veterinary Drugs Chemistry General Chemical Engineering 010401 analytical chemistry Extraction (chemistry) General Engineering Analytical chemistry 010402 general chemistry 01 natural sciences River water 0104 chemical sciences Analytical Chemistry Lc ms ms Enrichment factor Throughput (business) |
| Zdroj: | Analytical Methods. 9:4228-4233 |
| ISSN: | 1759-9679 1759-9660 |
| DOI: | 10.1039/c7ay01240c |
| Popis: | This study developed a method to perform the simultaneous determination of 58 (ultra) trace human and veterinary drugs in river water. The analytes included 24 steroid hormones, 22 sulfonamides and 12 quinolones. The easy-to-handle magnetic dispersive solid-phase extraction (Mag-dSPE) procedure was performed using three-dimensional interconnected magnetic chemically modified graphene oxide (3D-Mag-CMGO) as the adsorbent, and an enrichment factor of 100 times was obtained. Under the optimal conditions, the results showed higher extraction capacity of 3D-Mag-CMGO with recoveries between 78.0 and 109%. The limits of quantification (LOQs) for 58 (ultra) trace analytes are in the range of 0.10–2.09 ng L−1. Validation results on linearity, specificity, accuracy, and precision, as well as the application to the analysis of 58 (ultra) trace analytes in ten real samples demonstrated the applicability to environment monitoring analysis. |
| Databáze: | OpenAIRE |
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