ANTIPLASMODIAL ACTIVITY AND MALATE QUINONE OXIDOREDUCTASE INHIBITOR OF STEROID ISOLATED FROM Fibraurea tinctoria

Autor:	Riski Sulistiarini, Andreanus Andaja Soemardji, null Elfahmi, Maria Immaculata Iwo, Dian Japany Puspitasari, Erwahyuni Endang Prabandari, Danang Waluyo
Rok vydání:	2022
Předmět:	General Energy General Chemical Engineering parasitic diseases General Chemistry General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	Rasayan Journal of Chemistry. 15:377-386
ISSN:	0976-0083 0974-1496
DOI:	10.31788/rjc.2022.1516096
Popis:	Malaria is an infectious disease that causes 400,000 deaths every year. Based on that fact, antimalarial exploration needs to be developed. This study aimed to explore another compound in Fibraurea tinctoria that is known to have antiplasmodial activity from the berberine compound. Lactate dehydrogenase (LDH) assay and malate quinone oxidoreductase (pfMQO) inhibitor assay against Plasmodium falciparum 3D7 was used to evaluate the activity. The result showed that methanol extract, n-hexane fraction, n-hexane subfraction, and steroid compounds isolated from nhexane subfraction had the potential ability to inhibit the growth of Plasmodium falciparum 3D7 as well as the pfMQO enzyme. The results indicate that Fibraurea tinctoria may serve as a promising medicinal plant for future antimalarial drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f666791988dbc46d7798efbd8ae7d083 https://doi.org/10.31788/rjc.2022.1516096 Zobrazit plný text záznamu Plný text ve formátu PDF