Study on Clinical Factors Involved in Helicobacter pylori-Uninfected, Undifferentiated-Type Early Gastric Cancer
| Autor: | Toshiyuki Yoshio, Hiroshi Takahashi, Yorimasa Yamamoto, Masatsugu Nagahama, Masami Omae, Yusuke Horiuchi, Naoki Ishizuka, Toshiaki Hirasawa, Tomohiro Tsuchida, Akiyoshi Ishiyama, Junko Fujisaki |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology business.industry Gastroenterology Cancer Retrospective cohort study Helicobacter pylori medicine.disease biology.organism_classification Comorbidity Early Gastric Cancer 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cohort medicine 030211 gastroenterology & hepatology Medical history business Dyslipidemia |
| Zdroj: | Digestion. 96:213-219 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | Background: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. Methods: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014. This cohort consisted of 232 patients with HPPGC (82.3%) and 50 patients with HPUGC (17.7%). Patient characteristics were analyzed by subgroups of HPUGC vs. HPPGC, with comparisons for age, gender, cancer history, comorbidity of lifestyle diseases requiring medication (hypertension, type 2 diabetes, and dyslipidemia), cumulative amount of alcohol consumption, and smoking history (Brinkman index [BI]). Results: HPUGC patients were typically younger, had less frequent hypertension, and had higher BI values (p < 0.05 for all parameters). In a younger non-hypertensive subgroup, the OR for high BI (BI ≥340) in the HPUGC group vs. HPPGC group was 5.049 (95% CI 2.458–10.373, p < 0.0001). Conclusions: The investigation of clinical factors identified smoking history as being possibly contributing to the pathogenesis of HPUGC. Future research is necessary at the cellular and genetic levels. |
| Databáze: | OpenAIRE |
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