| Autor: |
L. Barnouin, Peter Verdonk, Ph Neyret, T. Ait Si Selmi |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Techniques in Knee Surgery. 6:253-258 |
| ISSN: |
1536-0636 |
| DOI: |
10.1097/btk.0b013e318148b797ab |
| Popis: |
Cartipatch is a third-generation autologous chondrocyte transplantation technique based on a chondrocyte-hydrogel combination specifically developed to overcome certain possible drawbacks of first- and second-generation techniques. A prospective phase 2 clinical study was launched on 20 patients for the treatment of osteochondral and osteochondritis dissecans lesion on the femoral condyle. Outcome parameters were clinical scores, magnetic resonance imaging, and arthroscopic biopsy at 2 years. All patients significantly improved clinically at 1 and 2 years. Six patients already reached the 2-year end point. Immunohistological examination revealed hyalinelike cartilage in all these cases. These results illustrate the feasibility of the Cartipatch technology. A reproducible, precise, and quick implantation of the hydrogels is obtained. The fixation of the cell-loaded hydrogels is guaranteed under in vivo circumstances. The limited immunohistological data already available at 2 years postimplantation show hyalinelike cartilage, indicating that these hydrogels support the phenotypical stability of the cultured articular chondrocytes both in vitro as well as in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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