Effect of stimulation of Kupffer cells by prodigiosan on regeneration of hepatocytes
| Autor: | V. I. Scherbakov, D. N. Mayanskii |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Mitotic index DNA synthesis Liver cytology Regeneration (biology) Prodigiosan Stimulation General Medicine Biology Polysaccharide General Biochemistry Genetics and Molecular Biology Endocrinology chemistry Internal medicine medicine Mitosis |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 86:915-917 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The effect of the polysaccharide ofBacillusprodigiosus (prodigiosan) on DNA synthesis and mitotic activity of the hepatocytes was studied in the regenerating liver of male Wistar rats. After administration of the stimulator in a dose of 50 μg per rat 24 h before partial hepatectomy the indices of labeled nuclei and mitotic indices were higher and reached their maximum sooner in the hepatocytes in the experimental animals than in the controls. It is suggested that the stimulating effect of prodigiosan is connected with activation of the Kupffer cells of the liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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