Impaired Assimilation of EGG CO57 Vitamin B12 in Patients With Hypochlorhydria and Achlorhydria and After Gastric Resection
| Autor: | Alfred Doscherholmen, William R. Swaim |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Hepatology Anemia business.industry medicine.medical_treatment digestive oral and skin physiology Feces analysis Gastroenterology Assimilation (biology) medicine.disease Achlorhydria Intestinal absorption Endocrinology Internal medicine medicine Gastrectomy Vitamin B12 business pernicious anemia |
| Zdroj: | Gastroenterology. 64:913-919 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(73)80002-2 |
| Popis: | Patients who have undergone gastric resection and those with simple gastric hypochlorhydria and achlorhydria may have low serum B 12 concentrations with normal absorption of radiocyanocobalamin. Impaired assimilation of food vitamin B 12 , but not of the crystalline Co 57 B 12 , may be the cause for this phenomenon. This hypothesis was tested by comparing the assimilation of Co 57 B 12 incorporated into eggs in vivo with that of crystalline Co 57 B 12 . As judged by the urinary excretion test, 10 patients with gastric resection having low serum B 12 , values and normal absorption of crystalline B 12 , absorbed on the average 9% of that observed in 11 normal control subjects when the egg Co 57 B 12 was administered. Similarly, 5 patients with achlorhydria or severe hypochlorhydria absorbed on the average 12% of that seen in normal subjects. There was no difference in the absorption of the crystalline Co 57 B 12 in these groups. An equally poor assimilation of nonlabeled food B 12 may explain the low serum B 12 concentrations found in postgastrectomy patients, and achlorhydric subjects with low serum B 12 and normal absorption of crystalline radiocyanocobalamin. Patients with pernicious anemia and those with gastric resection showing low serum B 12 concentrations and B 12 absorption values had extremely poor assimilation of both food Co 57 B 12 and crystalline Co 57 B 12 . |
| Databáze: | OpenAIRE |
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