Antibiosis, antibiotics, and the formaldehyde cycle: The unique importance of planar chromatographic techniques to progress in these fields

Autor: Zsuzsa Király-Véghely, György Kátay, Ágnes M. Móricz, Ernö Tyihák, Péter G. Ott
Rok vydání: 2004
Předmět:
Zdroj: Journal of Planar Chromatography – Modern TLC. 17:84-88
ISSN: 1789-0993
0933-4173
DOI: 10.1556/jpc.17.2004.2.1
Popis: The BioArena system, which integrates the up-to-date methodology and biological results of bioautography with OPLC as an efficient planar separation technique (compact spots, etc.), is especially suitable for investigating biochemical interactions in an adsorbent bed after chromatographic separation. The first results from BioArena show that formaldehyde (HCHO), which can originate from pathogen cells in some situations, can play a special role in the antibiotic activity of trans -resveratrol. When l -arginine and glutathione were used as endogenous HCHO-capturing molecules in the culture medium the antimicrobial activity of trans -resveratrol on the adsorbent layer decreased substantially. It has been observed that trans -resveratrol generates a time-dependent, and therefore concentration-dependent, duplicate inhibiting effect on the pathogen, and that the BioArena system was suitable for illustration of this new phenomenon. It is probable that this effect occurs as a result of HCHO, with special emphasi...
Databáze: OpenAIRE
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