Einfluß von Fenofibrat auf Fibrinogenkonzentration und Blutfluidität* 1: Konsequenzen für die myokardiale Mikrozirkulation bei der koronaren Herzerkrankung?
| Autor: | K. Joseph, B. E. Strauer, H. Blanke, H. Höffken, M. Leschke, R. Egbring, A. Schmidtsdorff |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Fenofibrate Cholesterol business.industry Blood viscosity General Medicine medicine.disease Fibrinogen Erythrocyte aggregation Microcirculation chemistry.chemical_compound Coronary circulation medicine.anatomical_structure chemistry Internal medicine medicine Cardiology Myocardial infarction business medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 114:939-944 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1066697 |
| Popis: | The effect of fenofibrate (a clofibrate derivative) on fibrinogen concentration, blood viscosity and myocardial microcirculation was examined in 35 patients with coronary heart disease (n = 27) or hypertension (n = 8). After eight weeks' administration of 250 mg fenofibrate daily cholesterol and triglycerides levels decreased significantly, as did the fibrinogen concentration, from a mean of 300.7 +/- 75.1 mg/dl to 252.3 +/- 61.2 mg/dl (P less than 0.01). Plasma viscosity and erythrocyte aggregation were also significantly lowered (from 1.43 +/- 0.09 to 1.37 +/- 0.07 mPas and 15.0 +/- 3.1 to 13.5 +/- 2.2, respectively; P less than 0.01). In eight of twelve subjects selected from the whole group thallium myocardial scintigraphy demonstrated, after eight weeks of treatment with fenofibrate, a global (in two) or regional (in six) increase in blood flow. Reduction of fibrinogen concentration may in coronary heart disease achieve an improvement in myocardial microcirculation with decreased myocardial ischaemia. |
| Databáze: | OpenAIRE |
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