Genomic Contraindications for Heart Transplantation
| Autor: | John D. Lantos, Michael J. Deem, Gabriel Lázaro-Muñoz, Danton S. Char, David Magnus, Aliessa Barnes |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Whole genome sequencing medicine.medical_specialty Pathology business.industry Genetic variants Bioethics 030105 genetics & heredity Genome DNA sequencing Transplantation 03 medical and health sciences Pediatrics Perinatology and Child Health Medicine Personalized medicine business Intensive care medicine |
| Zdroj: | Pediatrics. 139 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2016-3471 |
| Popis: | Genome sequencing raises new ethical challenges. Decoding the genome produces new forms of diagnostic and prognostic information; however, the information is often difficult to interpret. The connection between most genetic variants and their phenotypic manifestations is not understood. This scenario is particularly true for disorders that are not associated with an autosomal genetic variant. The analytic uncertainty is compounded by moral uncertainty about how, exactly, the results of genomic testing should influence clinical decisions. In this Ethics Rounds, we present a case in which genomic findings seemed to play a role in deciding whether a patient was to be listed as a transplant candidate. We then asked experts in bioethics and cardiology to discuss the implications of such decisions. |
| Databáze: | OpenAIRE |
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