Nailfold capillaroscopic examination and T786C endothelial nitric oxide synthase polymorphism in normal tension glaucoma patients

Autor: G Chodorowska, Dominika Wróbel-Dudzińska, J Bartosinska, Ewa Kosior-Jarecka, U Lukasik, Tomasz Zarnowski, J Kocki
Rok vydání: 2012
Předmět:
Zdroj: Acta Ophthalmologica. 90
ISSN: 1755-375X
DOI: 10.1111/j.1755-3768.2012.t014.x
Popis: Purpose The purpose of this study was assessment of nailfold capillary changes and their possible relation to polymorphism of a gene encoding endothelial nitric oxide synthase (eNOS) in normal tension glaucoma (NTG) patients Methods The study included 35 normal-tension glaucoma (NTG) patients (23 female and 12 male). Capillaroscopic examination of the nailfold capillaries of II to V fingers of both hands was performed (before and after the cold provocation test) by means of a videocapillaroscope. T786C eNOS gene polymorphism was determined by RT- PCR methods. Results 31 (88.6%) patients suffered from cold extremities. In 24 (68.5%) patients nailfold capillaroscopy was within normal limits, in 11 (31.5%) patients the results were abnormal, 4 (11.4%) of them mimicked changes observed in sclerodermia. The cold provocation test was positive in 43.5% of NTG patients. The patients with NTG presented the following nailfold capillaries: megacapilaries or dilatated capillaries (44.4%), ramified/bushy (18.9%), coiled (17.1%). Assessing the T786C polymorphism of eNOS gene in NTG patients, TT genotype was present in 36% patients, TC in 52.6% and CC in 11.3%. There were no correlation between SNP variants and capillaroscopy results nor cold provocation test ( p=0.9 and 0.5, respectively). Conclusion The T786C polymorphism of eNOS gene does not influence the capillaroscopy results. The high incidence of sclerodermia - like changes in capillaroscopy in NTG needs further studies.
Databáze: OpenAIRE
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