Precursor-Directed Biosynthesis of Talaroenamine Derivatives Using a Yellow River Wetland-Derived Penicillium malacosphaerulum
| Autor: | Xueqian He, Chao Niu, Lan-Ping Yang, Yang-Yang Zhai, Bao-Bao Zhang, Wang Zhenhui, Xiaomin Zhang, Jingchun Zhou, Dehai Li, Zhen-Zhen Liu, Huadong Li, Baohua Hou, Zhenzhen Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Penicillium malacosphaerulum biology Stereochemistry Organic Chemistry Reactive intermediate Bacillus cereus Pharmaceutical Science biology.organism_classification Analytical Chemistry chemistry.chemical_compound Aniline Complementary and alternative medicine chemistry Biosynthesis Drug Discovery Molecular Medicine |
| Zdroj: | Journal of Natural Products. 84:2923-2928 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.1c00696 |
| Popis: | Precursor-directed biosynthesis was used to introduce selected aniline derivatives into the talaroenamine pathway, which had recently been defined from a Yellow River wetland-derived Penicillim malacosphaerulum HPU-J01. The known talaroenamine B (1) and six previously undescribed talaroenamine derivatives, talaroenamines F-K (2-7), were generated and structurally characterized. The aniline derivatives are introduced via nonenzymatic addition to the reactive intermediate cyclohexanedione. Compound 2 was active against Bacillus cereus with an MIC value of 0.85 μg/mL. |
| Databáze: | OpenAIRE |
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