Synthesis of pyrido[2,3-d]pyrimidine-2,4-diones from pyrimido-[4,5-e]-1,2,4-triazine-6,8-diones by reversed azadiene synthesis

Autor:	V. V. Kuz'menko, Alexander F. Pozharskii, Anna V. Gulevskaya, A. I. Chernyshev, S. E. Esipov, Sergei V. Shorshnev
Rok vydání:	1990
Předmět:	Diethylamine chemistry.chemical_compound Pyrimidine chemistry Yield (chemistry) Organic Chemistry Acetone Organic chemistry Ether Chemical synthesis Medicinal chemistry Boron trifluoride Triazine
Zdroj:	Chemistry of Heterocyclic Compounds. 26:191-200
ISSN:	1573-8353 0009-3122
Popis:	It was shown that pyrimido[4,5-e]-1,2,4-triazine-6,8-diones enter the reversed azadiene synthesis reaction with ketones and vinyl ethyl ether in the presence of diethylamine or boron trifluoride etherate, and also with enamines. As a result of the reaction, pyrido[2,3-d]pyrimidine-2,4-diones are formed in good yield. Pyrimido[5,4-e]-1,2,4-triazine-5,7-diones do not undergo such reactions with acetone. The reasons for the unique behavior of the isomeric pyrimidotriazinediones in the reaction with acetone are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f61bbb9cdb57b9df1fa56f4fd4dbcab7 https://doi.org/10.1007/bf00499415 Zobrazit plný text záznamu Full text from SpringerLink