Decreased Fibrinolysis in Behçet’s Disease

Autor: G Izak, Eta Aronowski, Tova Chajek
Rok vydání: 1973
Předmět:
Zdroj: Thrombosis and Haemostasis. 29:610-618
ISSN: 2567-689X
0340-6245
DOI: 10.1055/s-0038-1648103
Popis: SummaryThe coagulation and fibrinolytic systems have been investigated in nine patients suffering from Behçet’s disease. Six of these had thrombophlebitis.The results of these studies revealed markedly elevated fibrinogen concentration and increased factor VIII activity as well as a pronounced decrease in the spontaneous fibrinolytic activity. This latter finding may have resulted from the presence of a potent antiplasmin activity and that of an inhibitor of the plasminogen activator detected in these patients’ sera.It is suggested that decreased fibrinolysis aggravates the thrombotic episodes frequently encountered in Behçet’s disease; accordingly treatment with fibrinolytic agents was found to offer marked benefits.
Databáze: OpenAIRE