Prevention of SV40 Virus Oncogenesis in Hamsters. II. The Effect of Thymectomy on Induction of Tumor Resistance by SV40-Transformed Human Cells
| Autor: | Anthony J. Girardi, Robert A. Roosa |
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| Rok vydání: | 1967 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 99:1217-1220 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Summary SV40 was inoculated into newborn hamsters and, 7 days later, some of the animals were thymectomized. On day 21 all hamsters received 350 r total body irradiation. Prior to the development of SV40-induced tumors, the thymectomized and non-thymectomized sets were subdivided further into two groups; one subgroup of each set was injected with SV40-transformed human cells; the other subgroup remained as controls. All animals were observed for development of SV40-induced tumors. The transformed cells induced tumor resistance only in the non-thymectomized host, thus indicating dependence on an intact lymphoid system for expression of tumor immunity, and showing that the cells most likely acted through their ability to stimulate a homograft rejection response. |
| Databáze: | OpenAIRE |
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