Hydrophilic lycopene-coated layered double hydroxide nanoparticles to enhance the antioxidant activity and the oxidative stress evaluation

Autor: Natália Alves de Matos, Gregorio Guadalupe Carbajal Arízaga, Norma Alejandra González Rojas, Dayne Kassandra Gutiérrez Galán, Jenny Arratia-Quijada, Fermín P. Pacheco-Moisés, Frank Silva Bezerra
Rok vydání: 2021
Předmět:
Zdroj: Applied Nanoscience. 11:2747-2758
ISSN: 2190-5517
2190-5509
DOI: 10.1007/s13204-021-02205-8
Popis: Lycopene is well known as an efficient natural antioxidant; however, its hydrophobic structure limits intestinal absorption through the epithelium by conventional food. Oil-based edibles containing tomato increase the bioavailability of lycopene; therefore, the preparation of emulsions emerged as a solution to prepare lycopene supplements. This work reports the preparation of a composite with lycopene and layered double hydroxides (LDH) nanoparticles. Four LDH compositions were studied of which MgAl–Cl, MgAl–CO3, ZnAl–Cl and ZnAl–CO3, were their combinations. Hydrodynamic size and zeta potential were measured in aqueous suspensions for all the composites. Lycopene maintains its antioxidant capability within the magnesium-based composites and it is synergized in the zinc-containing LDHs. The improved hydrodispersability of the composites allowed us to assess the antioxidant capacity and the oxidative stress protection in conventional aqueous assays, which are limited for traditional oily lycopene formulations. The cation composition of the LDH influenced the antioxidant capacity; however, those containing magnesium presented a non-toxic performance in the oxidative stress assays. The obtained composites demonstrated to be an alternative to design lycopene aqueous formulations or increase its bioavailability.
Databáze: OpenAIRE
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