Bitolterol Mesylate (WIN 32784) Aerosol
| Autor: | Irving Kass, Thomas S. Mingo |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chronotropic Vital capacity medicine.medical_specialty medicine.drug_class business.industry Prodrug Pharmacology Critical Care and Intensive Care Medicine Esterase Endocrinology Bronchodilator Internal medicine medicine Catecholamine Onset of action Bitolterol Mesylate Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Chest. 78:283-287 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.78.2.283 |
| Popis: | Bitolterol mesylate (WIN 37284) is α-[ tert -butylamino-methyl]-3,4-dihydroxybenzyl alcohol 3,4-di( p -toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is a "prodrug" which is inactive until altered in the body. The intact 3,4-diester molecule is metabolized by esterase hydrolysis to release the active catecholamine, N - t -butylarterenol. Because the level of esterase is greater in the pulmonary tissue than in the heart, bitolterol mesylate aerosol was shown to be an effective bronchodilator drug, without any significant cardiac side effects. The onset of action was rapid and lasted more than six hours. The improvement over baseline values in the forced expiratory volume in the first second and the mean forced expiratory flow during the middle half of the forced vital capacity was greater than 15 percent and 30 percent, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|