Brain imaging in childhood- and adolescence-onset schizophrenia associated with obsessive-compulsive symptoms
| Autor: | Kazuya Hata, Junzo Iida, F. Aoyama, Makoto Inoue, Hidemi Iwasaka, S. Sakiyama, Toshifumi Kishimoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.diagnostic_test Putamen Hippocampus Magnetic resonance imaging Corpus callosum medicine.disease behavioral disciplines and activities Psychiatry and Mental health Neuroimaging Frontal lobe Schizophrenia otorhinolaryngologic diseases medicine Etiology Psychiatry Psychology |
| Zdroj: | Acta Psychiatrica Scandinavica. 102:32-37 |
| ISSN: | 0001-690X |
| DOI: | 10.1034/j.1600-0447.2000.102001032.x |
| Popis: | Objective: Childhood- and adolescence-onset schizophrenic patients with obsessive-compulsive symptoms (OCS) constitute a specific subgroup of schizophrenia. We performed magnetic resonance imaging in this group seeking evidence of neurodevelopmental insults. Method: Thirty-two schizophrenic patients were compared with 19 controls. Schizophrenic subjects were divided into 15 patients with OCS (SOCS+ group; onset at 15.5±1.6 years) and 17 without OCS (SOCS− group; onset at 15.3±1.3 years). Areas of the hippocampus, frontal lobe, corpus callosum and putamen were analysed morphometrically. Results: The left hippocampus was significantly smaller in the SOCS+ group than in the SOCS− and control groups. Conclusion: Reduced size of the left hippocampus in the SOCS+ group supports a neurodevelopmental etiology in this subgroup. |
| Databáze: | OpenAIRE |
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