Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

Autor:	Gail L. Wrigley, Shaun M. Fillery, Barry M. Hayter, Paula Perkins, Jason Grant Kettle, Emma J. Williams, Peter Mark Smith, Mandy L. Crowther, Rebecca J. Burton, Peter Robins, Neal J. Fazakerley, Caroline Anne McMillan
Rok vydání:	2013
Předmět:	Chemistry Reagent Organic Chemistry Drug Discovery Regioselectivity Buchwald–Hartwig amination Biochemistry Combinatorial chemistry Chemical space Amination
Zdroj:	Tetrahedron Letters. 54:6900-6904
ISSN:	0040-4039
Popis:	The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f60a61ec4c2e6a3963dffd65b51aad7e https://doi.org/10.1016/j.tetlet.2013.10.035 Zobrazit plný text záznamu Full Text from ScienceDirect