A rational designed thiols fluorescence probe: the positional isomer in PET
| Autor: | Jianjian Zhang, Haixia Zhang, Xiaoyan Liu, Hong Gao, Xinyue Zhu, Xiao-Jun Yao, Wenyan Zan, Yan Li, Fengchao Qi, Xuan Wei |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Fluorophore 010405 organic chemistry Organic Chemistry Electron donor Electron acceptor 010402 general chemistry Photochemistry 01 natural sciences Biochemistry Fluorescence Photoinduced electron transfer 0104 chemical sciences Fluorescence intensity chemistry.chemical_compound chemistry Drug Discovery Thiol Maleimide |
| Zdroj: | Tetrahedron. 72:2048-2056 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2016.03.013 |
| Popis: | It was reported here a devised and synthesized thiol fluorescent probes ortho-Z3, meta-Z3 and para-Z3 based on photoinduced electron transfer (PET) pathway utilizing fluorophore naphthalimide as the electron donor and responsive group maleimide as the electron acceptor. The fluorescence intensity of these probes varied significantly depending on the position of the maleimide toward the naphthalimide fluorophore. Comparing to the meta and para isomers, the ortho isomer displayed the best fluorescence response performances upon addition of thiols. The results indicated that relative position of the electron acceptor played key role in the PET process, and probe ortho-Z3 could detect endogenous biothiols in serum samples and live cells successfully. |
| Databáze: | OpenAIRE |
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