| Autor: |
Rosa E. Menjivar, Hu B, Costas A. Lyssiotis, Charlestin, Shuze Wang, Pasca di Magliano M, Samantha Kemp, Zeribe C. Nwosu, Jun Hu, Nassif M, Nina Steele, Giza H, David D. Kim |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.05.28.446056 |
| Popis: |
Genomic profiling has unveiled the molecular subtypes and mutational landscape of pancreatic ductal adenocarcinoma (PDAC). However, there is a knowledge gap on the consistency of gene expression across PDAC tumors profiled in independent studies and this limits follow up research. To facilitate novel drug target prioritization and biomarker discovery, we investigated the most consistently expressed genes in human PDAC. We identified ~4,000 genes highly or lowly expressed in at least 4 of 5 microarrays (adjusted PHighlightsIdentifies ~4,000 consistent genes across PDAC microarrays, >50% of which have not been studiedGlycolysis and cell cycle are the most consistent processes in PDACHeterogeneous pathways underlie or correlate with clinicopathological variablesIdentifies 205 genes with similar expression pattern in PDAC tissues and peripheral bloodHighlights 185 upregulated genes that are high priority therapeutic targets in PDAC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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