| Autor: |
Raymond J. Connolly, C R Valeri, J Vecchione, P. Kahn, A Ucci, K Ramberg, T O’Donnell, G Bottomley, Allan D. Callow, Ronald M. Gembarowicz |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Oral Presentations. |
| ISSN: |
2567-689X |
| DOI: |
10.1055/s-0038-1652550 |
| Popis: |
In a primate model (Papio papio) whose coagulation system is similar to man, we have previously shown that Indium-111 labeled platelets (IN111) are taken up acutely in the region of a synthetic graft. IN111 uptake was maximal by 48 hours post-graft implantation and was no greater at 7 days. The purpose of the present study was to detail platelet-graft dynamics during later phases after graft implantation. IN111 platelets were infused intravenously into animals two weeks after implantation of a 4 mm synthetic carotid artery interposition graft. The radioactivity in the region of the graft was contrasted to a comparable blood volume in a control artery and this activity was calculated by a computer algorithm which accounted for isotopic decay and tissue attenuation. Radioactivity was expressed as % of the total injected dose of IN111 (%TID). The difference (%TID on graft - %TID on control artery) was calculated to determine platelet-graft associated activity. Histologic sections were subsequently examined to correlate graft morphology with in vivo dynamic changes. Results: The mean uptake of IN111 platelet associated activity during the early post graft implantation phase ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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